From Marinum to Ulcerans: a Mycobacterial Human Pathogen Emerges
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From Marinum to Ulcerans: a Mycobacterial Human Pathogen Emerges Lateral gene transfers and genome reduction apparently remodeled a fish pathogen into the agent that causes Buruli ulcer in humans
H ave you heard of Buruli ulcer? Probably not, unless you come from equatorial Africa, Papua New Guinea, the Daintree region in tropical Northern Australia, or seaside towns in temperate South Eastern Australia. Other than sporadic cases among visitors to these endemic zones, Buruli ulcer does not occur in North American or European countries. However, the surge and severity of this disease in ...
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متن کاملA newly discovered mycobacterial pathogen isolated from laboratory colonies of Xenopus species with lethal infections produces a novel form of mycolactone, the Mycobacterium ulcerans macrolide toxin.
Mycobacterium ulcerans, the causative agent of Buruli ulcer, produces a macrolide toxin, mycolactone A/B, which is thought to play a major role in virulence. A disease similar to Buruli ulcer recently appeared in United States frog colonies following importation of the West African frog, Xenopus tropicalis. The taxonomic position of the frog pathogen has not been fully elucidated, but this orga...
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ژورنال
عنوان ژورنال: Microbe Magazine
سال: 2007
ISSN: 1558-7452,1558-7460
DOI: 10.1128/microbe.2.187.1